MISMS Africa

Dakar, Senegal, Apr 21-25, 2009

Our first regional MISMS meeting for Africa was held in Dakar, Senegal, on April 21-25, 2009, co-sponsored by the Institut Pasteur de Dakar, at Le Meridien President Conference Center, Dakar. Participants from all regions of Africa attended the workshop.

Participants at MISMS Dakar

Participants at MISMS Dakar

Agenda for MISMS Africa Meeting
Day 1- Tuesday April 21st – General meeting part 1

11:00am-1:30 Registration

12:30-1:30 Lunch (buffet lunch provided)

1:30-3:15 Session I. Welcome and MISMS highlights

  1. Welcome address and/or Opening speech (IPD/MoH/TBC)
  2. Mark Miller, Fogarty International Center, National Institutes of Health, USA: Overview of Multinational Influenza Seasonal Mortality Study; Integrating mortality, virological, vaccine and genomic data to infer influenza epidemiology (20′ talks +10′ questions)
  3. Cécile Viboud, Fogarty International Center, NIH Influenza transmission studies and mortality impact (20′ talks +10′ questions)

3:15-3:45 Coffee break

 3:45-5:15  Session II. MISMS highlights and influenza in Africa

  1. Katharine Sturm-Ramirez, Fogarty International Center, NIH. Migration patterns and evolution of A/H5N1 in Africa (20′ talks +10′ questions)
  2. Cheryl Cohen, NICD, South Africa: Influenza excess mortality in South African seniors  (20′ talks +10′ questions)
  3. Ousmane Diop, Pasteur Institute, Dakar: Developing Influenza Surveillance in Africa (20′ talks +10′ questions)

5.15-5:30: Logistics / house-keeping issues

Day 2 – Wednesday April 22 – General meeting part II

8:45-10:20 Session III. Ecology and surveillance of highly-pathogenic avian influenza viruses – part I


  1. Jean-Claude Manuguerra, Pasteur Institut, France: Survival of avian influenza viruses in the environment: the RIVERS project (20′ talks +5′ questions)
  2. Jean-Michel Takuo, Global Viral Forecasting, Cameroon: Interactions between wild and domestic birds in central Africa: opportunities for cross-species transmission of avian influenza viruses (10′ talks +5′ questions)


  1. Clement Meseko, Food and Agriculture Organization, Nigeria: Detection of Highly Pathogenic Avian Influenza (A/H5N1) in asymptomatic waterfowls in live bird markets, Nigeria (10’ talk)
  2. Michael Adjabeng,Ghana Health Services, Ghana: Disease Surveillance activities in response to Avian Influenza outbreaks: the Ghanais experience (10’ talk)
  3. Bangana Ibrahim, Ministry of breeding and animal Industries, Niger Lessons Learnt from past outbreaks and surveillance of Avian Influenza in Niger (10’ talk)
  4. Ibrahim Bangana, Ministry of Breeding and Animal Industries, Niger Lessons Learnt from past outbreaks and surveillance of Avian Influenza in Niger (10’ talk)
  5. Question Session for surveillance talks (15’)

10:25-10:55 Coffee break

10:55-11:40 am Session IV. Surveillance of highly-pathogenic avian influenza viruses – part II

  1. Bernard Erima, Makere University Walter Reed Avian Influenza Project, Uganda: Surveillance of high-path influenza in Avian and human populations in Uganda (10′ talk)
  2. David Olaleye, Department of Virology, University of Ibadan, Nigeria: Seroprevalence study of A/H5 influenza among live bird traders in Nigeria (10′ talk)
  3. Amadou Diaite, Laboratoire National de l’Elevage et de Recherches Vetérinaires, Senegal: Avian influenza surveillance activities in Senegal (10′ talk)
  4. Question Session for surveillance talks (15’)

11:40-1:10 Session V. Surveillance of seasonal influenza viruses, influenza-like-illnesses and severe acute respiratory infections

  1. Barnabas Bakamutumaho, National Influenza Center, Uganda Virus Research Institute: Human influenza surveillance in Uganda: experience from the adoption of the PAHO-CDC and WHO-AFRO influenza surveillance protocols. (20’ talk + 5’ questions)
  2. Marietjie Venter, University of Pretoria, South Africa: Contribution of common and recently described viruses to respiratory hospitalizations in HIV-positive and negative children, South Africa (10’ talk)
  3. Serge Manoncourt, US Navy Medical Research Unit 3, Egypt. Contribution for a better knowledge of influenza and other respiratory viruses in West African countries (10’ talk)
  4. Mark Katz, Global Diseases Detection Division, Center for Diseases Control and Prevention, Kenya: Population-based surveillance of ILI and SARI in Nairobi and Western Kenya (10’ talk)
  5. Remy Michel, Pasteur Institute, Senegal: Reinforcement of influenza surveillance in Senegal in 2008 (10’ talk)
  6. Benjamin Rihenhour, Center for Diseases Control and Prevention, USA. Spatial and temporal modeling of seasonal influenza epidemics. (10’ talk)
  7. Question Session for human influenza surveillance (15’)

12:45-2:00 Lunch (buffet lunch provided)

2:10-3:30 Session VI. Genetic and Antigenic Evolution of Influenza Viruses Evolution, Anti-viral Resistance, Vaccines

  1. Eddie Holmes, Pennsylvania State University and Fogarty International Center, USA: Ecology and evolution of human influenza A viruses (20’ talk +10’ questions)
  2. Colin Russell, Cambridge University and Fogarty International Center, USA: Antigenic mapping and global circulation of influenza viruses (15’ talk +5’ questions)
  3. Wallace Bulimo, US Army Medical Research Unit, Kenya: Molecular Characterization and Phylogenetic Analysis of Human Influenza A/H1N1 Viruses Circulating in Kenya, 2007-2008 (10’ talk +5’ questions)
  4. Odile Ouwe Missi Oukem, Centre International de Référence Chantal Biya, Cameroon: Exploring the impact of immune pressure on the molecular evolution of human influenza virus in Sub Saharan Africa (10’ talk+5’ questions)

3:30-4:00 Coffee break

4:00-5:15 Session VII. Emergence of anti-viral resistance

  1. Martha Nelson, Fogarty International Center, National Institutes of Health, USA: Global emergence of adamantane resistance in human influenza A/H3N2 viruses (20’ talk +10’ questions)
  2. Dhamari Naidoo, National Institute for Communicable Diseases, South Africa: Surveillance of neuraminidase inhibitor resistance in South Africa, 2007-08 (10’ talk)
  3. William Kwabena Ampofo, Noguchi Institute, Ghana: Initiation of Influenza virus surveillance in Ghana, West Africa (10’  talk)
  4. Vincent Enouf, Pasteur Institute, France: Emergence of Oseltamivir resistance in influenza A/H1N1 virus: the French experience (10’ talk)
  5. Question Session for Oseltamivir resistance talks (15’)

5:15-6:15 Session VIII. Options for future collaborations

  1. Maria Giovanni, NIH; David Spiro, JCVI: The NIAID/NIH influenza sequencing project (20’ talk +10’ questions)
  2. Wrap-up (Mark Miller, Fogarty International Center, National Institutes of Health, USA)


Day 3: Thursday April 23 – Workshop

  • Time series and spatial analysis 101 (introduction to workshop, MISMS Staff, NIH, USA)
  • Phylogenetics 101 (introduction to workshop, MISMS Staff, NIH, USA)
  • How to participate in the NIAID influenza sequencing project (Maria Giovanni, NIH, USA & David Spiro, JCVI, USA)
  • Presentation of the NIAID BioHealth database project (NIAID/NIH contractor/TBD)

Hands-on tutorial, small working groups, flexible schedule

10:30-11:00 Coffee break; 12:30-1:30pm Lunch (buffet lunch provided); 3:00-3:30 Coffee break

Day 4: Friday April 24 – Workshop

Hands-on tutorial, small working groups, flexible schedule

10:30-11:00 Coffee break

12:30-1:30 Lunch (buffet lunch provided)

3:00-3:30 Coffee break

Day 5: Saturday April 25 – Workshop

Hands-on tutorial, small working groups, flexible schedule

10:30-11:00 Coffee break;

Workshop ends at 11.30 am



Workshops for epidemiologists and virologists led by the US National
Institutes of Health Fogarty International Center

Following the meeting, a workshop describing the methodology to evaluate vital statistics,
virological, genomic and economic data to describe influenza disease burden and
inform policy will be held. It will consist of workshops designed for epidemiologists/virologists
and policy-makers who are interested in evaluating datasets which may be brought
to the meeting for further analysis. Workshops will concentrate on methodologies
to evaluate time-series data for regional or national analysis of influenza disease
burden, assessments of control, and evolution of influenza viruses. Participants
will have the opportunity to learn and apply tools to analyze national datasets
and formulate further collaborations on bi-national and multinational studies.
Please note that participation in the Thursday and Friday workshop sessions will
be limited. Participation will be based on submitted abstracts which should include
a description of available datasets that participants may want to further analyze.

It is highly recommended, but not required, that participants in the workshop bring:
– a laptop with some type of statistical software (SAS recommended)
– an influenza dataset (vital statistics data, influenza isolate data, and vaccine coverage)

Individuals who attend the workshop will have the opportunity to learn about:
– time series analysis
– spatial / temporal relationships
– influenza genomics tools
– data management issues
– SAS / Stata code – go home with your own programs
– strategies for evaluating vaccine benefits in a country using mortality data
– and more