MISMS Influenza Workshop:

Fogarty International Center, National Institutes of Health

November 7-10, 2016, Bethesda, MD

Participants from four continents convene at the Stone House for the 2016 MISMS workshop

Participants from four continents convene at the Stone House for the 2016 MISMS workshop

No registration fee!


The Fogarty International Center of the U.S. National Institutes of Health (NIH) is holding an influenza research workshop on the NIH campus in Bethesda, MD from November 7 – 10, 2016. This will be the 17th regional meeting held as part of the FIC-initiated MISMS project, an international research collaboration to study flu data using state-of-the-art methods of epidemiologic and phylogenetic analysis. Hosting the workshop at the NIH provides the opportunity for better integration between the experimental work underway at NIH intramural and those studying evolution and epidemiology.  We encourage speakers to present unpublished or recently accepted work.

Accommodation: Guests often stay at the DoubleTree hotel in Bethesda.  The American Inn is a less expensive option and also within walking distance of the NIH.

Important Reminders!

US participants: don’t forget to VOTE on November 8tharrange to vote early if traveling to the meeting

Metro Red Line single tracking  Please add extra time for the commute.  Details available here.


Software downloads: Those participating in the workshop should download these free software prior to the workshop.

Time series/epidemiology





Phylogenetic analysis

BEAST [includes BEAST, BEAUTi, TreeAnnotator]

[if possible also download latest version 1.8.4 at github]







Phylodynamics Tutorial (+ data sets)


Update your Java (important)





Draft Agenda

MISMS Workshop, Bethesda, MD
November 7-10, 2016


Schedule at-a-glance:

Monday November 7 – Tuesday November 8: Scientific sessions

Wednesday November 9 – Thursday November 10: Technical workshop


Monday November 7:  Research workshop

9:00-9:30: Registration

9:30-9:40:  Cecile Viboud – Welcome and MISMS overview (FIC)

9:40-10:40: Session I: Immunity and Pathogenesis (10′ + 10′ discussion). Moderator: Jack Bennink, NIAID

Michael Worobey, Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting (U Arizona)

Matthew Memoli, Immunological correlates of protection (NIAID)

Scott Hensley, Immune history and seasonal influenza virus susceptibility (U Penn)

10:40-11:10: Coffee break

11:10-12:10: Session II: Vaccine (10′ + 10′ discussion). Moderator: Carol Weiss, FDA

Janelle Rowell, Impact of previous exposures on universal vaccine performance (FDA)

Wladimir Alonso, Timing of influenza vaccine in the tropics: the impact of a decade of research (FIC)

Suman Das, Improving influenza vaccine preparedness through predictive bioinformatics and synthetic genomics (Vanderbilt)


12:10-1:40: Lunch break


1:40-2:40: Session III: Transmission Dynamics (10′ + 10′ discussion). Moderator: Sue Epstein, FDA

Montserrat Torremorell, Investigations into the airborne transmission of influenza viruses in swine and poultry (U Minnesota)

Donald Milton, Influenza virus aerosols generated by naturally and experimentally infected adults (U Maryland)

Justin Lessler, Is it Groundhog Day? Year-to-year consistency of human contact patterns in southern China and its implications (Johns Hopkins U) 

2:40-3:00: Session IV: Evolution and Immunity (10′ + 10′ discussion). Moderator: David Spiro, NIH

Alice Fusaro, Host immunity shapes the intra-host evolution of an H3N6 avian influenza virus in ferrets (IZSVe)

3:00-3:30: Coffee break

3:30-4:10: Session IV, cont’d

Eili Klein, Linking influenza HA biophysical properties, virus fitness in vitro, and global virus sequence changes (Johns Hopkins U)

Matthew Angel, Influenza escape from broadly neutralizing antibodies (NIAID)

4:10-5:00: Session V: Pandemic Influenza (10′ + 10′ discussion). Moderator: Jeff Taubenberger, NIAID.

Martha Nelson, The evolution of pandemic influenza viruses in swine (FIC)

John Kash, 1918 pandemic influenza virus and Streptococcus pneumoniae co-infection results in activation of coagulation and widespread pulmonary thrombosis in mice and humans (NIAID)

Short talks by workshop participants (5′ + 5′ discussion)

Nacho Mena, Analysis of the 2009 and 2010 seasons of pandemic influenza in Chile (Mt Sinai)


7.00pm: Social event: Dinner at Bangkok Garden, 4906 St Elmo Ave., Bethesda MD 20814


Tuesday November 8: Research workshop

Late start to provide extra time for voting in general elections


10:00-11:00: Session VI: New Methods for Surveillance and Forecasting (10′ + 10′ discussion). Moderator: Shweta Bansal, Georgetown University

Andrew Rambaut, Spatial molecular epidemiology of acute viral epidemics using real-time genomic sequencing (U Edinburgh)

Gerardo Chowell, To grow exponentially or not? Implications for forecasting influenza epidemics and beyond (Georgia State U)

Short talks by workshop participants (5′ + 5′ discussion)

Simon Pollett, Evaluating Google Flu Trends in Latin America: lessons for the next phase of digital disease detection (U Sydney)

Han-Yi Chiu, Establishing a Radio-based Archipelago Syndromic Surveillance System (RASSS) in the Marshall Islands during the Epidemic of Influenza in 2016 (Nat’l Taiwan U)

11:00-11:30: Coffee break

11:30-12:30: Session VII: Seasonality and Spatial Diffusion (10′ + 10′ discussion). Moderator: Cécile Viboud, NIH

Sinead Morris, Influenza synchrony in Norway (Princeton U)

Elizabeth Lee, Identifying drivers of spatial heterogeneity in influenza disease burden (Georgetown U)

Short talks by workshop participants (5′ + 5′ discussion)

Ting-Chia Weng, Predicting clinical severity for pediatric versus elderly patients hospitalized with influenza-like illness in Taiwan (Nat’l Taiwan U)

Fabian Chamba, Influenza prevalence, seasonality and weather association in US Midwestern breed-to-wean pig farms (U Minnesota)


12:30-2:00: Lunch break


2:00-3:00: Session VIII: Evolutionary Dynamics (10′ + 10′ discussion). Moderator: Andrew Rambaut, U Edinburgh

Philippe Lemey, Variable tick rates and white noise in viral molecular clocks (KU Leuven)

Nidia Trovao, Bayesian inference reveals host-specific contributions to the epidemic expansion of Influenza A H5N1 (FIC)

Short talks by workshop participants (5′ + 5′ discussion)

Bianca Zecchin, Genetic characterization of H5N1 viruses collected in West Africa between 2015-2016 (ISZVe)

Constantinos Kyriakis, Evolution of influenza in swine in the Southeast United States (UGA)

3:00-3:30: Coffee break

3:40-4:20: Session VIII, cont’d  Short talks by workshop participants (5′ + 5′ discussion)

Sulochana Manandhar, Surveillance of influenza A virus and its subtypes in migratory wild birds of Nepal (Center for Molecular Dynamics Nepal)

Guadalupe Ayora-Talavera, Genetic variants of influenza A(H1N1)pdm09 virus in Southern Mexico (Universidad Autonoma de Yucatan)

Juan Cristina, Phylogenetic analysis of the neuraminidase gene of pandemic H1N1 Influenza A virus circulating in the South American region (Universidad de la República, Uruguay)

Chwan-Chuen King, Integrated influenza surveillance and epidemiological informatics (Nat’l Taiwan U)


7.00pm: Social event TBD

Wednesday November 9: Technical Workshop

Led by MISMS staff and collaborators: Wladimir Alonso, Gerardo Chowell, Philippe Lemey, Martha Nelson, Andrew Rambaut, Nidia Trovao, Cecile Viboud

09:30-10:30: Time-series analyses I

10:30-11:00: Coffee break

11:00-12:00: Reproduction number estimation and disease modeling

12:00-1:30: Lunch break

1:30-2:30: Phylogenetics 101; intro to BEAST

2:30-3:00: Coffee break

3.00-5.00: Working time

Thursday November 10: Technical Workshop

9:30-5:00: Working time: Hands-on tutorials, small group collaboration, one-on-one instruction

10:30-11:00: Coffee break

12:00-1:30: Lunch break

3:00-3:30: Coffee break