MISMS: a global collaboration to study influenza

  • 18-year program to advance evidence-based policies for influenza control in the US and globally
  • Includes basic research and training workshops led by a core team of scientists at Fogarty International Center (FIC), based at the US National Institutes of Health.
  • MISMS staff annually organize training workshops to teach methods of data analysis, including time-series, modeling, and phylogenetic analysis
  • Develops global collaborations to facilitate data-sharing and large-scale studies of disease dynamics
  • Focus on low- and middle-income countries

MISMS training workshop in South Africa, 2018

Examples of how MISMS research impacted policy decision-making:

Improving influenza vaccination strategies during pandemics based on the age-shift from elderly to younger adults

Seasonal influenza vaccine campaigns in children, who are key vectors of transmission in communities, can provide indirect protection to vulnerable seniors with low immune responses to vaccination and high mortality.

Advising countries in tropical and sub-tropical regions on whether to use the Northern hemisphere or Southern hemisphere vaccine formulation, based on the seasonal timing of their influenza epidemics, which tends to be more variable than the winter epidemics seen in temperate regions.

Recognizing role of humans in transmitting influenza viruses to animals (reverse zoonosis), including transmission of pandemic H1N1 viruses from humans to swine and to zoo animals.

Timing of waves of previous pandemics, NEJM 2009 

Recent Updates

What can social networks tell us about the epidemiology of the 2019-2020 Coronavirus outbreak?

MISMS staff use social network data to study the epidemiology of the COVID-19 outbreak in China in a study published this week in Lancet Digital Health.

Early childhood ‘imprinting’ influences infection with seasonal viruses

MISMS researchers show that birth year-specific differences in childhood immune imprinting explain why adults tend to be infected with H3N2 seasonal viruses while H1N1 mainly infects children in a study published in PLoS Pathogens: ‘Childhood immune imprinting to influenza A shapes birth year-specific risk during seasonal H1N1 and H3N2 epidemics‘.

MISMS MinION Workshop – Colombia

Training Workshop for the Implementation of MinION Sequencing for Influenza Viruses  February 6-8, 2020 Irotama Resort Santa Marta, Colombia Workshop Objective This three-day workshop, held February 6-8th, 2020 in Santa Marta, Colombia, introduced new technologies and advanced informatics approaches that can be used for infectious disease genomic characterization in resource-limited settings. Using the portable, low-cost […]